SYNERGISTIC ANTIMICROBIAL EFFECT OF COLISTIN IN COMBINATION WITH ECONAZOLE AGAINST MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII AND ITS PERSISTERS

Synergistic Antimicrobial Effect of Colistin in Combination with Econazole against Multidrug-Resistant Acinetobacter baumannii and Its Persisters

ABSTRACT Colistin is a last-line antibiotic which acts by causing membrane permeabilization in Gram-negative bacteria.However, its clinical value has been limited by its toxicity and the emergence of resistant organisms.In this study, we showed that econazole and colistin can act synergistically to produce a strong antimicrobial effect sufficient f

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